研究実績・活動

教育研究業績(論文)

Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RGW, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet 2017 Jan:49(1): 75-86. Doi: 10.1038/ng.3711

新宮多加志、Jian Hu. クエイキング欠損はニッチ外でがん幹細胞の幹細胞性を維持させる. 実験医学 35:978-980, 2017 (Current Topics)

Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L, Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki to coactivate PPARb-RXRa-mediated lipid metabolism. J Clin Invest. 2020; 130(5):2220-2236: pii: 131800. Doi:10.1172/JCI131800.

Ren J, Dai C, Zhou X, Barnes J, Chen X, Wang Y, Yuan L, Shingu T, Heimberger A, Chen Y, Hu J. Qki is an essential regulator of microglia phagocytosis in demyelination. J Exp Med. 2021 Jan 4; 218(1):e20190348 Doi:10.1084/jem.20190348

Zhou X, Shin S, He C, Zhang Q, Rasband MN, Ren J, Dai C, Zorrilla-Veloz RI, Shingu T, Yuan L, Wang Y, Chen Y, Lan F, Hu J. Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. eLife 2021: 10:e60467 Doi: 10.7554/eLife.60467

Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021 May 21;12(1):3005. Doi: 10.1038/s41467-021-22782-0.

Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, Harris AL, Zuniga AM, Mullinax RA, Ma X, Seth S, Daniele JR, Peoples MD, Loponte S, Akdemir KC, Khor TO, Feng N, Roszik J, Sobieski MM, Brunell D, Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A. Sequential administration of XPO1 and ATR inhibitors enhances therapeutic responses in TP53-mutated colorectal cancer. Gastroenterology 2021 Jul; 1616(1): 196-210. Doi:10.1053/j.gastro.2021.03.022

Immune landscape of a genetically engineered murine model of glioma compared with human glioma. Zamler DB, Shingu T, Kahn LM, Huntoon K, Kassab C, Ott M, Tomczak K, Liu J, Li Y, Lai I, Zorilla-Veloz R, Yee C, Rai K, Kim BY, Watowich SS, Heimberger AB, Draetta GF, Hu J.JCI Insight. 2022 Jun 22;7(12):e148990. doi: 10.1172/jci.insight.148990.　2022年6月

Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma ・ Frontiers in Cell and Developmental Biology ・ Aksoy Yasar FBf, Shingu Tf, Zamler DB, Zaman MF, Chien DL, Zhang Q, Ren J and Hu J, 10:931387. doi: 10.3389/fcell.2022.931387 2022 (f: These authors contributed equally to this work and share first authorship)　2022年8月

Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease. Chen CH, Chin RL, Hartley GP, Lea ST, Engel BJ, Hsieh CE, Prasad R, Roszik J, Shingu T, Lizee GA, Heimberger AB, Millward SW, Hu J, Hong DS, Curran MA: Neuro Oncol. 2023 Aug 3;25(8):1415-1427. doi: 10.1093/neuonc/noad025.・2023年8月

食餌組成や回転ケージによる自発運動、緑茶カテキン摂取が高脂肪食摂取肥満マウスの代謝に及ぼす影響・東海学園大学研究紀要・新宮多加志、熊崎柚香、寺嶋正治・第28号　自然科学研究編・2024年3月

教育研究業績(その他)

Invited peer-review: Autophagy, Biochemical Pharmacology, Biochimie, Biomedicines, Cancers, Cells, Cellular Physiology and Biochemistry, Frontiers in Oncology, International Journal of Developmental Neuroscience, International Journal of Molecular Sciences, International Journal of Radiation Biology, Journal of Cellular Biochemistry, Journal of Experimental and Clinical Cancer Research, Journal of Membrane Biology, Journal of Pediatric Hematology and Oncology, Medical Oncology, Molecular and Cellular Biochemistry, Molecular Cancer, Molecular Cancer Research, Neurological Research, OncoTargets and Therapy, Pharmacology.

外部リンク

https://researchmap.jp/read0161956